News News Blog: Angelina Jolie

Arthritis drug may boost survival rates for those with ‘Angelina Jolie gene’

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BREAKTHROUGH research has revealed an arthritis drug may improve the prognosis for ovarian cancer patients with the BRCA1 mutation.</h2>
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<tr><td class="tr-caption" style="text-align: center;">An arthritis drug may boost survival rates for those with ‘Angelina Jolie gene’ </td></tr>
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The anti-rheumatic medication is providing significant hope for thousands of patients suffering from ovarian cancer, a study has revealed.</div>
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The “highly promising” find shows the drug Auranofin can kill off ovarian cancer cells in women with deficiencies of the gene. </div>
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The arthritis drug reduces survival rates of BRCA1-deficient cancerous cells by over a third, the study revealed. </div>
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<tr><td class="tr-caption" style="text-align: center;">Auranofin can kill off ovarian cancer cells in women with deficiencies of the gene</td></tr>
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BRCA1 - popularly known as the Angelina Jolie gene - is a tumour-suppressing gene because of its ability to guide the repair of damaged DNA.</div>
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The gene is mutated in 15-20 per cent of ovarian cancer cases and carriers of the deficiency are predisposed to the potentially deadly disease.</div>
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A mutation of the BRCA1 gene can also increase the likelihood of developing breast cancer.</div>
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Ms Jolie underwent a double mastectomy and had her ovaries removed after learning she had carried a gene mutation linked to breast and ovarian cancers.</div>
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<tr><td class="tr-caption" style="text-align: center;">The BRCA1 is mutated in 15-20 per cent of ovarian cancer cases</td></tr>
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The actress, 40, had an 87 per cent risk of developing breast cancer and 50 per cent risk of developing ovarian cancer.</div>
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Awadhesh Jha, Professor of Toxicology and Associate Head (Research) in the School of Biological Sciences said: “Using drugs such as Auranofin to treat cancer is highly promising since they are readily available and their pharmacological and toxicological properties are well documented. </div>
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“Studies carried out with cells grown under laboratory conditions showed faults in the BRCA1 gene render these cells more vulnerable to Auranofin compared to ovarian cancer cells with normal BRCA1 genes. </div>
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“It suggests that Auranofin has the potential to be considered for future clinical studies to treat such ovarian cancers and this could serve as the spring board to use other available drugs which are not used as chemotherapeutic drugs.”</div>
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<tr><td class="tr-caption" style="text-align: center;">Researchers want to look at other non-chemotherapeutic drugs in the fight against cancer</td></tr>
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The exciting discovery also has the potential to be used as a “spring board” for scientists to look at other available drugs that aren’t chemotherapeutic drugs in treating cancer. </div>
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Dr Dennis Yiannakis, Clinical Oncologist at the Plymouth Hospitals NHS Trust, added: “Our collaboration has focused on the field of DNA repair (particularly BRCA 1/2 mutated states) and its relevance to ovarian and lung cancer. </div>
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“The project is investigating the accurate diagnosis of faults in high fidelity DNA repair and how to manipulate it for therapeutic benefit in patients. This is an emerging area of potential ways of treating these cancers.”</div>
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Arthritis drug may boost survival rates for those with ‘Angelina Jolie gene’

BREAKTHROUGH research has revealed an arthritis drug may improve the prognosis for ovarian cancer patients with the BRCA1 mutation. ...

‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body

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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhQUs7jFvSJVk0GiRGq9BsOFD0XJSZoXlxEbG3wogDNAzFe6d0l4LWntr_z5WD9c8-0yVURPvjxyKFir1o-fGtEpLEfA3zPIZYbwzgeJ0xDXppANGN2dznAgmiwgMjis9UWMaVkPhSuHhyphenhypheny/s1600/%25E2%2580%2598Angelina+Jolie+syndrome%25E2%2580%2599+sees+health-obsessed+taking+extreme+action+to+protect+body.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhQUs7jFvSJVk0GiRGq9BsOFD0XJSZoXlxEbG3wogDNAzFe6d0l4LWntr_z5WD9c8-0yVURPvjxyKFir1o-fGtEpLEfA3zPIZYbwzgeJ0xDXppANGN2dznAgmiwgMjis9UWMaVkPhSuHhyphenhypheny/s640/%25E2%2580%2598Angelina+Jolie+syndrome%25E2%2580%2599+sees+health-obsessed+taking+extreme+action+to+protect+body.jpg" title="‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Being cautious with health has been dubbed 'Angelina Jolie syndrome' by some people</td></tr>
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HEALTH-CONSCIOUS men and women are increasingly taking extreme action to self-preserving against the risk of fatal diseases.</div>
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Worried patients are becoming so “obsessed” they are even going under the knife to have surgery.</div>
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The desire for a young, beautiful, slim body has become a “calculation of sickness” according to a new research article in the Journal of Social Policy Studies.</div>
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The obsession with appearing to lead a healthy life is also leading those seen as unhealthy being shunned in social circles.</div>
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<tr><td class="tr-caption" style="text-align: center;">The lecturer says we have become obsessive with monitoring health</td></tr>
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An awareness of developing certain health conditions has even be labelled by some as ‘Angelina Jolie syndrome’ after the actress made the brave decision to have a double mastectomy and ovaries removed after blood test raised fears she was in the early stages of cancer.</div>
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From a boom in diets, fitness, plastic surgery, organic foods and monitoring our wellbeing on apps and with gadgets, Evgenia Golman, lecturer at the HSE Faculty of Social Sciences Department of General Sociology, revealed health has never been so important in society. </div>
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The senior lecturer even believes that being unhealthy can be a source of stigmatisation and that everything that doesn’t fit in to these healthy standard becomes at risk of discrimination.</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXtYgDaRT3y1bHJdHZTyYKbmLUqdzs9M-Io9eLh8eMu47WyfoXOOPNqlQ5Vinncf0J8-ZbhTnqK4iS4LMUD-es1yOr6MbJ1IK3xWaMy1AUQZFBa2xikxBu52SBADNNPUXMx9c_fGyLySoY/s1600/%25E2%2580%2598Angelina+Jolie+syndrome%25E2%2580%2599+sees+health-obsessed+taking+extreme+action+to+protect+body+3.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXtYgDaRT3y1bHJdHZTyYKbmLUqdzs9M-Io9eLh8eMu47WyfoXOOPNqlQ5Vinncf0J8-ZbhTnqK4iS4LMUD-es1yOr6MbJ1IK3xWaMy1AUQZFBa2xikxBu52SBADNNPUXMx9c_fGyLySoY/s640/%25E2%2580%2598Angelina+Jolie+syndrome%25E2%2580%2599+sees+health-obsessed+taking+extreme+action+to+protect+body+3.jpg" title="‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">According to the report, there is a pursuit in idealised body standards</td></tr>
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In extreme forms, healthism can become obsessive, leading to an “individual’s regular supervision of their body”, according to Golman. </div>
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She claims people are beginning to obsessively monitor every body manifestation and starts detecting signs of imaginary sickness.</div>
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Golan added: “Popular healthcare policy today often shifts the responsibility for health from healthcare institutions to individuals themselves, and shifts the focus from treatment to prevention, including prevention of even purely hypothetical pathologies.”</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhdxpMICsr240OaDhudATkL8aj8wwry5OtjBwdZoZO2YK5cvvciGqVTTMw2Yp13gi2yUtivaE-lGybqZWmAyZIDAKJxLPmbjr_XLkf8SKL9mKTiwrWlKCc2oEsPuXYVvV1UAIOGPbtSB8gA/s1600/%25E2%2580%2598Angelina+Jolie+syndrome%25E2%2580%2599+sees+health-obsessed+taking+extreme+action+to+protect+body+4.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhdxpMICsr240OaDhudATkL8aj8wwry5OtjBwdZoZO2YK5cvvciGqVTTMw2Yp13gi2yUtivaE-lGybqZWmAyZIDAKJxLPmbjr_XLkf8SKL9mKTiwrWlKCc2oEsPuXYVvV1UAIOGPbtSB8gA/s640/%25E2%2580%2598Angelina+Jolie+syndrome%25E2%2580%2599+sees+health-obsessed+taking+extreme+action+to+protect+body+4.jpg" title="‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">We have seen a rise in surgery, organic eating habits and health monitoring</td></tr>
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The lecturer said goal of healthcare becomes not only about feeling well, but looking good and these idealised body standards can lead to mass neurosis and a social obsession. </div>

‘Angelina Jolie syndrome’ sees health-obsessed taking extreme action to protect body

Being cautious with health has been dubbed 'Angelina Jolie syndrome' by some people HEALTH-CONSCIOUS men and women are in...

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