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Marouane Fellaini replaces injured Manchester United captain Wayne Rooney as Louis van Gaal makes three changes to the side that drew with Leicester last time out.
Rooney picked up an ankle injury which rules him out, while Jesse Lingard has shaken off a minor hamstring to replace Ashley Young out wide.
Anthony Martial will once again lead the line, and further back Morgan Schneiderlin replaces Michael Carrick.
 
Paddy McNair keeps his place as an injury to Marcos Rojo means the back four is unchanged.
West Ham have lost Diafra Sakho for up to eight weeks, so Andy Carroll is back up front for Slaven Bilic's side.
The biggest surprise is Manuel Lanzini, who does not feature in the match day squad, while Carl Jenkinson and Pedro Obiang are replaced by Mark Noble and Alex Song.
 
Manchester United: De Gea, Darmian, McNair, Smalling, Blind, Schneiderlin, Schweinsteiger, Mata, Fellaini, Lingard, Martial.
Subs: Romero, Pereira, Borthwick-Jackson, Carrick, Young, Memphis, Varela.
West Ham: Adrian, Tomkins, Reid, Ogbonna, Cresswell, Song, Noble, Kouyate, Moses, Zarate, Carroll.
Subs: Randolph, Jenkinson, Collins, Obiang, Oxford, Antonio, Jelavic.

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