News News Blog: Parkinson's disease

How excess iron damages the brain and contributes to Parkinson’s disease

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EXCESS iron in your brain might be harming your health, study finds.</h3>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjs7uqAOVU42P5rtc53e8dIP9U08d2IviCYfagVjJc8F104i8xXuJeWb4kxvBxTtbxzlDYjJFaoNFmKUAMI_bwUmugy2pnjZgrv0G6puV4FgEr_fWPcBMfMOTVAC_8p9k0UFiydOT6rLNKg/s1600/How+excess+iron+damages+the+brain+and+contributes+to+Parkinson%25E2%2580%2599s+disease.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="How excess iron damages the brain and contributes to Parkinson’s disease" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjs7uqAOVU42P5rtc53e8dIP9U08d2IviCYfagVjJc8F104i8xXuJeWb4kxvBxTtbxzlDYjJFaoNFmKUAMI_bwUmugy2pnjZgrv0G6puV4FgEr_fWPcBMfMOTVAC_8p9k0UFiydOT6rLNKg/s640/How+excess+iron+damages+the+brain+and+contributes+to+Parkinson%25E2%2580%2599s+disease.jpg" title="How excess iron damages the brain and contributes to Parkinson’s disease" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Iron levels have long been associated with PD, but this study looked at how</td></tr>
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It’s long been known large amounts of the mineral are found in the brains of patients with Parkinson’s, but it’s true effects have not been clear - now scientists may have unveiled the answer.</div>
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Researchers at the Buck Institute for Research on Ageing discovered that excess iron damages neurons in the brain by impairing structures called lysosome which repair damage.</div>
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This process has been proven to play a role in ageing and neurodegenerative diseases.</div>
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<tr><td class="tr-caption" style="text-align: center;">Inner workings of a human cell: Lysosomes are intrinsic in repairing damage</td></tr>
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As we get older, this rebuilding slows down and causes “garbage” to build up inside cells and creates toxic stress.</div>
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Senior scientist Julie K Andersen said: “It's recently been realised that one of the most important functions of the lysosome is to store iron in a place in the cell where it is not accessible to participate in toxic oxidative stress-producing reactions. </div>
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"Now we have demonstrated that a mutation in a lysosomal gene results in the toxic release of iron into the cell resulting in neuronal cell death."</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgOzALlYVEiBkD1I4diKbjB5o05FPBwOJmO3xrp1C5C3xJKe0188-ZFAGrERe17HCztRdIPUSsCHZArgzt0ZhyphenhyphenWBgDJ-b6MakVa90nrLWIKlheskeZnBCGpPBpPrPk5m4Zuq14Rr-z6nVod/s1600/How+excess+iron+damages+the+brain+and+contributes+to+Parkinson%25E2%2580%2599s+disease+3.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="How excess iron damages the brain and contributes to Parkinson’s disease" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgOzALlYVEiBkD1I4diKbjB5o05FPBwOJmO3xrp1C5C3xJKe0188-ZFAGrERe17HCztRdIPUSsCHZArgzt0ZhyphenhyphenWBgDJ-b6MakVa90nrLWIKlheskeZnBCGpPBpPrPk5m4Zuq14Rr-z6nVod/s640/How+excess+iron+damages+the+brain+and+contributes+to+Parkinson%25E2%2580%2599s+disease+3.jpg" title="How excess iron damages the brain and contributes to Parkinson’s disease" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">As we get older the rebuilding slows down and impairs brain activity</td></tr>
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She added: “This suggests that age-related impairments in lysosomal function that impact the ability of neurons to maintain a healthy balance of iron are part of what underlies the presentation of PD in the general population.”</div>
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Dr Andersen has a long-standing interest in the role of excess iron and Parkinson’s disease. </div>
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In a previous study, she showed tying up excess iron with a metal chelator protected mice from the ravaging effects of the well-known Parkinson's inducing toxin, MPTP.</div>
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<tr><td class="tr-caption" style="text-align: center;">Left right connections in a brain with Parkinson's</td></tr>
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Findings were published in The Journal of Neuroscience.</div>
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In the UK around 1 in 500 are affected by Parkinson’s disease. </div>
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Every hour, someone in the UK is told they have the degenerative condition, according to Parkinson’s UK.</div>
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How excess iron damages the brain and contributes to Parkinson’s disease

EXCESS iron in your brain might be harming your health, study finds. Iron levels have long been associated with PD, but this stu...

Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers

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SCIENTISTS have discovered a commonly prescribed drug may provide a crucial lifeline for those suffering from Parkinson’s disease.</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjSA9v7jco6wt9Jf2xu1IenmEqv2dGL0kdM1yo9SbCxp-81dAolFUr4vUZVpM-LDVN1DKBn8IoY7J2S9MYl2yrrNkFii8pJoAplN9Vv7_nmL51TFW-ogs07OYyDRkmkMOcUmUrE7x9f64RB/s1600/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjSA9v7jco6wt9Jf2xu1IenmEqv2dGL0kdM1yo9SbCxp-81dAolFUr4vUZVpM-LDVN1DKBn8IoY7J2S9MYl2yrrNkFii8pJoAplN9Vv7_nmL51TFW-ogs07OYyDRkmkMOcUmUrE7x9f64RB/s640/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers.jpg" title="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Scientists have made a breakthrough discovery regarding Parkinson's</td></tr>
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Bone-breaking injuries suffered by people with the illness could be reduced thanks to the medication, a study has found.</div>
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Around 70 per cent of people with Parkinson's will fall at least once a year, with over a third experiencing falls repeatedly, resulting in fractures, broken bones and hospital admissions, the report published in the Lancet Neurology journal said.</div>
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The breakthrough revealed the rivastigmine drug reduced this chance of falling by 45 per cent and steadied walking at the same time.</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjKuSvBUHTrFMQYFve5slcJSeSQVyvsOoDeJdPNF70mPv6GCRTaEdWz9c1a4eeER8XqV2O-AStWBRMdn02P7yhCOjAmHjZZwwp_KsvNaaHXVeAK-WwX7Iei5y9wvF4VEJcyt4gJRUU61R2C/s1600/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers+2.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjKuSvBUHTrFMQYFve5slcJSeSQVyvsOoDeJdPNF70mPv6GCRTaEdWz9c1a4eeER8XqV2O-AStWBRMdn02P7yhCOjAmHjZZwwp_KsvNaaHXVeAK-WwX7Iei5y9wvF4VEJcyt4gJRUU61R2C/s640/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers+2.jpg" title="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Parkinson's sufferers are prone to falling</td></tr>
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The oral drug is commonly prescribed in the treatment of mild to moderate Alzheimer's to help improve symptoms including those affecting thinking and memory.</div>
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Over an eight-month period, scientists from the University of Bristol gave the drug to half of a group of 130 Parkinson's sufferers who had fallen in the last year.</div>
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Study participant Caroline Maxwell, from Northamptonshire, said the treatment would give her the "confidence" to leave the house by herself.</div>
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Mrs Maxwell, who was diagnosed with Parkinson's 13 years ago, said: "A few years ago, I had a bad fall while carrying my sewing machine across the room, leaving me in hospital for a week and really denting my confidence.</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiWKPvflenNqscsHUAdiqd-OB3nECNhYrTCelY7ZXmtcy-JRGL2WHm7bOnEYKn81w_z4CByDO4hTrhvrVaZdwwBCuJ7nZV5DIPLm6lmbGzx7t4jIubUrigPyWdeeb6xBQbL97jiQLmkC58C/s1600/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers+3.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiWKPvflenNqscsHUAdiqd-OB3nECNhYrTCelY7ZXmtcy-JRGL2WHm7bOnEYKn81w_z4CByDO4hTrhvrVaZdwwBCuJ7nZV5DIPLm6lmbGzx7t4jIubUrigPyWdeeb6xBQbL97jiQLmkC58C/s640/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers+3.jpg" title="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Dementia meds could be the answer in preventing dangerous falls</td></tr>
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"I'm at the stage where I would walk much better with a replacement joint, but because I fall so frequently my surgeon is reluctant to operate. Falling on my replacement hip would put in an even worse situation than what I'm in now.</div>
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"By potentially finding a treatment that helps to prevent falls, I'd be able to get a replacement hip and have the confidence to go shopping on my own, without having to constantly rely on the goodness of strangers to pick me up when I fell."</div>
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Parkinson's is a disease which worsens over time, slowing the movement of those who suffer from it, as well as leading to tremors. Sadly, there is currently no cure.</div>
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Around one in every 500 of the population, or 127,000 people, suffer from the incredibly debilitating condition in the UK, according to the charity Parkinson's UK, which helped fund the study.</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiinUnEdOYEpjGjEgxU35xydwSS2sUq_tOe0fhyphenhyphen-nYk7dKRZtYd-m4RTivfyZpZSOd2_kO9LKZBwxGJX1ZgTLmjyZ03PK72xwdlVCvPcFIEr-pv5dFpJJi9MW6KK1kSvdYanbvbm3CvA5aG/s1600/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers+4.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" border="0" height="378" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiinUnEdOYEpjGjEgxU35xydwSS2sUq_tOe0fhyphenhyphen-nYk7dKRZtYd-m4RTivfyZpZSOd2_kO9LKZBwxGJX1ZgTLmjyZ03PK72xwdlVCvPcFIEr-pv5dFpJJi9MW6KK1kSvdYanbvbm3CvA5aG/s640/Common+dementia+drug+is+a+%25E2%2580%2598real+breakthrough%25E2%2580%2599+for+Parkinson%25E2%2580%2599s+sufferers+4.jpg" title="Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers" width="640" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Sadly, no cure has yet been discovered </td></tr>
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Lead researcher and Parkinson's UK research fellow Dr Emily Henderson said: "With the degeneration of dopamine-producing nerve cells, people with Parkinson's often have issues with unsteadiness when walking.</div>
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"As part of the condition, they also have lower levels of acetylcholine, a chemical which helps us to concentrate - making it extremely difficult to pay attention to walking.</div>
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"We already know that rivastigmine works to treat dementia by preventing the breakdown of acetylcholine, however our study shows for the first time that it can also improve regularity of walking, speed, and balance. This is a real breakthrough in reducing the risk of falls for people with Parkinson's."</div>
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Common dementia drug is a ‘real breakthrough’ for Parkinson’s sufferers

SCIENTISTS have discovered a commonly prescribed drug may provide a crucial lifeline for those suffering from Parkinson’s disease. ...

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