News News Blog: Gene

Arthritis drug may boost survival rates for those with ‘Angelina Jolie gene’

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BREAKTHROUGH research has revealed an arthritis drug may improve the prognosis for ovarian cancer patients with the BRCA1 mutation.</h2>
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<tr><td class="tr-caption" style="text-align: center;">An arthritis drug may boost survival rates for those with ‘Angelina Jolie gene’ </td></tr>
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The anti-rheumatic medication is providing significant hope for thousands of patients suffering from ovarian cancer, a study has revealed.</div>
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The “highly promising” find shows the drug Auranofin can kill off ovarian cancer cells in women with deficiencies of the gene. </div>
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The arthritis drug reduces survival rates of BRCA1-deficient cancerous cells by over a third, the study revealed. </div>
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<tr><td class="tr-caption" style="text-align: center;">Auranofin can kill off ovarian cancer cells in women with deficiencies of the gene</td></tr>
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BRCA1 - popularly known as the Angelina Jolie gene - is a tumour-suppressing gene because of its ability to guide the repair of damaged DNA.</div>
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The gene is mutated in 15-20 per cent of ovarian cancer cases and carriers of the deficiency are predisposed to the potentially deadly disease.</div>
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A mutation of the BRCA1 gene can also increase the likelihood of developing breast cancer.</div>
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Ms Jolie underwent a double mastectomy and had her ovaries removed after learning she had carried a gene mutation linked to breast and ovarian cancers.</div>
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<tr><td class="tr-caption" style="text-align: center;">The BRCA1 is mutated in 15-20 per cent of ovarian cancer cases</td></tr>
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The actress, 40, had an 87 per cent risk of developing breast cancer and 50 per cent risk of developing ovarian cancer.</div>
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Awadhesh Jha, Professor of Toxicology and Associate Head (Research) in the School of Biological Sciences said: “Using drugs such as Auranofin to treat cancer is highly promising since they are readily available and their pharmacological and toxicological properties are well documented. </div>
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“Studies carried out with cells grown under laboratory conditions showed faults in the BRCA1 gene render these cells more vulnerable to Auranofin compared to ovarian cancer cells with normal BRCA1 genes. </div>
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“It suggests that Auranofin has the potential to be considered for future clinical studies to treat such ovarian cancers and this could serve as the spring board to use other available drugs which are not used as chemotherapeutic drugs.”</div>
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<tr><td class="tr-caption" style="text-align: center;">Researchers want to look at other non-chemotherapeutic drugs in the fight against cancer</td></tr>
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The exciting discovery also has the potential to be used as a “spring board” for scientists to look at other available drugs that aren’t chemotherapeutic drugs in treating cancer. </div>
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Dr Dennis Yiannakis, Clinical Oncologist at the Plymouth Hospitals NHS Trust, added: “Our collaboration has focused on the field of DNA repair (particularly BRCA 1/2 mutated states) and its relevance to ovarian and lung cancer. </div>
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“The project is investigating the accurate diagnosis of faults in high fidelity DNA repair and how to manipulate it for therapeutic benefit in patients. This is an emerging area of potential ways of treating these cancers.”</div>
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Arthritis drug may boost survival rates for those with ‘Angelina Jolie gene’

BREAKTHROUGH research has revealed an arthritis drug may improve the prognosis for ovarian cancer patients with the BRCA1 mutation. ...

Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes

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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjpxVMw9AhIARPXfbgE964ZDHF4aIbjyeA-gCWOrb4aRtG0Vgl_Tv5bFsC0yfCTLvHdaTs5qZo9akr5_ygNYkh1FPcpNhbxj_eKSJ1VYa3I4P_XwjvM1pbWrNKCqpsPe1FmTuR6vJ9aS0EO/s1600/Cancer+ISN%2527T+in+your+genes-+Nine+out+of+10+cancers+are+caused+by+lifestyle+NOT+bad+genes.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes" border="0" height="640" src="" title="Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes" width="596" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">The vast majority of cancers are caused by environmental factors research suggests</td></tr>
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NINE in 10 cancers are caused by unhealthy lives rather than bad genes, new evidence shows.</div>
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Scientists say factors in the modern world such as bad diet, smoking cigarettes, sunlight, and disease, play a far bigger role than random DNA mutations in causing cancer.</div>
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Researchers went on to say that as many as 90 per cent of cases would be wiped out if we could “magic away” all external factors.</div>
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This contradicts a study published in January which found that 65 per cent of cancers were inevitable and caused by random mistakes in cell division.</div>
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<tr><td class="tr-caption" style="text-align: center;">Bad diet is a major factor in causing cancer</td></tr>
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Dr Yusuf Hannun, of Stony Brook University in the US, said that while luck and genetics plays a role, factors in the world around us are much more important.</div>
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            These results demonstrate that a large proportion of cancer is caused by environmental factors        </div>
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Dr Jian-Min Yuan, of the University of Pittsburgh</div>
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Writing in the journal Nature, he said that the genes we inherit from our parents only account for a very small number of cancer cases.</div>
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He said: “These results are important for forming strategies for cancer prevention, research and public health.”</div>
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Experts said he had built a “compelling case” for his argument.</div>
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Professor Kevin McConway, of the Open University, said: “The author’s aim is to calculate what percentage of cancers would not arise, if we could wave a magic wand and get rid of all possible external risk factors. There would still be cancers, because of the way that cells divide in the body. But there would be fewer of them.”</div>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhMbL6eyHAisGbWzAtp_O8N1stYov53TV2j_V4NHgBqv0i299XArpdaI7l-jjzEkxwFfKdRntGSG4l0ETW5rbCtDsqY7BFSEaxiLfaHTq_xkWu2SHNOSS0V70oMcvo3cr6wulKrSby_GfP9/s1600/Cancer+ISN%2527T+in+your+genes-+Nine+out+of+10+cancers+are+caused+by+lifestyle+NOT+bad+genes+3.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes" border="0" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhMbL6eyHAisGbWzAtp_O8N1stYov53TV2j_V4NHgBqv0i299XArpdaI7l-jjzEkxwFfKdRntGSG4l0ETW5rbCtDsqY7BFSEaxiLfaHTq_xkWu2SHNOSS0V70oMcvo3cr6wulKrSby_GfP9/s640/Cancer+ISN%2527T+in+your+genes-+Nine+out+of+10+cancers+are+caused+by+lifestyle+NOT+bad+genes+3.jpg" title="Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes" width="596" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Smoking tobacco leads to lung, throat and mouth cancer </td></tr>
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<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhs90bmfzztr9dGdGNG-zB_hFL651qY4cgGQHAUhqoBP8oMHEaHpDQaYwtGGkv4MNOCUh_Wmxu3RkQpfFD3rK10jlReOOXSl4kcoJPnOKNGxWECAArpjrJPYoNyKJEd-53oExyW6WQlBcbN/s1600/Cancer+ISN%2527T+in+your+genes-+Nine+out+of+10+cancers+are+caused+by+lifestyle+NOT+bad+genes+4.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes" border="0" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhs90bmfzztr9dGdGNG-zB_hFL651qY4cgGQHAUhqoBP8oMHEaHpDQaYwtGGkv4MNOCUh_Wmxu3RkQpfFD3rK10jlReOOXSl4kcoJPnOKNGxWECAArpjrJPYoNyKJEd-53oExyW6WQlBcbN/s640/Cancer+ISN%2527T+in+your+genes-+Nine+out+of+10+cancers+are+caused+by+lifestyle+NOT+bad+genes+4.jpg" title="Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes" width="596" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Ultraviolet rays from the sun can damage skin cells </td></tr>
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Dr Jian-Min Yuan, of the University of Pittsburgh in the US, said: “These results demonstrate that a large proportion of cancer is caused by environmental factors and are preventable if their underlying causes are identified.”</div>
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A spokesman for Cancer Research UK, said: “Healthy habits like not smoking, keeping a healthy weight, a healthy diet and cutting back on alcohol are not a guarantee against cancer, but they do dramatically reduce the risk of developing the disease.”</div>
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Cancer ISN'T in your genes: Nine out of 10 cancers are caused by lifestyle NOT bad genes

The vast majority of cancers are caused by environmental factors research suggests NINE in 10 cancers are caused by unhealthy liv...

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